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سدیم استات تری هیدرات 106235 مرک Sodium acetate trihydrate 106235 merck
سدیم استات تری هیدرات 106235 مرک
Sodium acetate trihydrate 106235 merck
Sodium acetate trihydrate suitable for use as an active pharmaceutical ingredient EMPROVE® api Ph Eur,BP,JP,USP,FCC,E 262.
| Product Information | |
|---|---|
| CAS number | 6131-90-4 |
| EC number | 204-823-8 |
| Grade | Ph Eur,BP,JP,USP,FCC,E 262 |
| Hill Formula | C₂H₃NaO₂ * 3 H₂O |
| Chemical formula | CH₃COONa * 3 H₂O |
| Molar Mass | 136.08 g/mol |
| HS Code | 2915 29 00 |
| Structure formula Image | |
| Applications | |
|---|---|
| Application | Sodium acetate trihydrate suitable for use as an active pharmaceutical ingredient EMPROVE® api Ph Eur,BP,JP,USP,FCC,E 262. CAS No. 6131-90-4, EC Number 204-823-8. |
| Physicochemical Information | |
|---|---|
| Density | 1.42 g/cm3 (20 °C) |
| Flash point | >250 °C (anhydrous substance) |
| Ignition temperature | 607 °C |
| Melting Point | 58 °C |
| pH value | 7.5 - 9.2 (50 g/l, H₂O, 20 °C) |
| Bulk density | 900 kg/m3 |
| Solubility | 613 g/l |
| Toxicological Information | |
|---|---|
| LD 50 oral | LD50 Rat 3530 mg/kg |
| LD 50 dermal | LD50 Rabbit > 10000 mg/kg |
| Safety Information according to GHS | |
|---|---|
| RTECS | AJ4580000 |
| Storage class | 10 - 13 Other liquids and solids |
| WGK | WGK 1 slightly water endangering |
| Disposal | 14 Inorganic salts: Container I. Neutral solutions of the these salts: Container D. Before placing in Container D, check the pH with pH-Universal indicator strips (Item No. 109535). |
| Storage and Shipping Information | |
|---|---|
| Storage | Store at +2°C to +25°C. |
| Transport Information | |
|---|---|
| Declaration (railroad and road) ADR, RID | Kein Gefahrgut |
| Declaration (transport by air) IATA-DGR | No Dangerous Good |
| Declaration (transport by sea) IMDG-Code | No Dangerous Good |
| Specifications | |
|---|---|
| Assay (perchloric acid titration, calculated on dried substance) | 99.5 - 101.0 % |
| Identity | passes test |
| Appearance of solution | passes test |
| In water insoluble matter | ≤ 0.03 % |
| Alkalinity | ≤ 0.05 % |
| Acidity or alkalinity | passes test |
| pH-value (1 %, water) | 8.0 - 9.5 |
| pH-value (5 %; water) | 7.5 - 9.0 |
| Chloride (Cl) | ≤ 0.005 % |
| Sulphate (SO₄) | ≤ 0.003 % |
| Heavy metals (as Pb) | ≤ 0.0006 % |
| Al (Aluminium) | ≤ 0.00002 % |
| As (Arsenic) | ≤ 0.0002 % |
| Ca (Calcium) | ≤ 0.002 % |
| Fe (Iron) (*) | ≤ 0.001 % |
| Hg (Mercury) | ≤ 0.0001 % |
| K (Potassium) | ≤ 0.005 % |
| Mg (Magnesium) | ≤ 0.001 % |
| Pb (Lead) | ≤ 0.0002 % |
| Ca + Mg (calcium and magnesium) | passes test |
| free acetic acid | ≤ 0.4 % |
| Other residual solvents (Ph.Eur./USP/ICH) | excluded by manufacturing process |
| formic acid, formate and other oxidizable impurities | ≤ 0.1 % |
| Substances reducing potassium permanganate (as HCOOH) | passes test |
| Loss on drying (130 °C) | 39.0 - 40.5 % |
| * specified acc. to EMEA/CHMP/SWP/4446/2000.Other residues of metal catalysts or metal reagents acc. to this guideline are not likely to be present. | |
| Corresponds to Ph Eur,BP,JP,USP,FCC,E 262 Conforms to the purity criteria on food additives according to the current European Commission Regulation. |
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